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Sildenafil Softgel
Sildigra Softgel

  • Sildenafil Softgel
  • ED018
  • In Stock

Premium High Quality Product & Original Active Substance!

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   Manufacturer's Suggested Retail Price (MSRP) per pill is $6.21 ! Buying from us will save you at least 37.84%

Package per pill Price SAVINGS BONUS Order
100mg * 10 pills
$3.86 $38.60 $0.00
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100mg * 20 pills
$2.06 $41.20 $36.00
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100mg * 30 pills
$2.59 $77.70 $38.10
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100mg * 40 pills
$2.24 $89.60 $64.80
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100mg * 50 pills
$2.04 $102.00 $91.00
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100mg * 60 pills
$1.92 $115.20 $116.40
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100mg * 70 pills
$1.88 $131.60 $138.60
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100mg * 80 pills
$1.81 $144.80 $164.00
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100mg * 90 pills
$1.77 $159.30 $188.10
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100mg * 120 pills
$1.61 $193.20 $270.00
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100mg * 150 pills
$1.44 $216.00 $363.00
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100mg * 180 pills
$1.34 $241.20 $453.60
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Sildenafil is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).

One Sildigra Softgel capsule should be taken with water whole, without chewing, breaking or crushing it. In a 24-hour span, only one capsule should be taken, or it will lead to overdosing and harm the individual's health. It should also be taken after a meal, but care should be taken to ensure that the meal is neither fatty nor heavy. For a more rigid erection, men should provide a gap of about 30-45 minutes after taking the medicine.

Erections are controlled by the parasympathetic nervous system. Upon sexual stimulation, a decrease in vascular resistance is mediated by acetylcholine and nitric oxide resulting in vasodilation. The hemodynamic mechanism of an erection is comprised of five stages. During the latent stage, arterial and carvernous smooth muscle relaxation occurs. Vasodilation results in high levels of blood flow causing the penis to grow to its full size. This stage is called tumescence.

During the full-erection stage, blood flow fills penis sinusoids and outflow is restricted. This is followed by the rigid-erection phase during which the cavernous muscles contract causing the penis to become rigid. Little blood flow occurs during this stage. During the final stage, detumescence, the cavernous muscles relax and blood flows out of the penis. Erectile dysfunction may occur when there is insufficient blood supply to the penis or when the penis is unable to prevent outflow of blood from the penis.

Sildenafil is a specific inhibitor of PDE5, an enzyme responsible for the breakdown of cGMP to 5’-GMP. Increased levels of cGMP stimulate vasodilation and facilitate the generation and maintenance of erections. These vasodilatory effects also help decrease symptoms of PAH. Sildenfail also exhibits some activity against PDE6 (10 times less potentcy compared to PDE5), a PDE isoform found predmoninantly in the retina. This activity is responsible for the blue tinged vision experienced by users of sildenafil.

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle.

This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Metabolism: Sildenafil appears to be completely metabolized in the liver to 16 metabolites. Its metabolism is mediated mainly by cytochrome P450 microsomal isozymes 3A4 (major route) and 2C9 (minor route). The major circulating metabolite, N-demethylated metabolite, has PDE selectivity similar to the parent drug and ~50% of its in vitro potency. The N-demethylated metabolite is further metabolized to an N-dealkylated N,N-de-ethylated metabolite. Sildenafil also undergoes N-dealkylation followed by N-demethylation of the piperazine ring.

Absorption: >90% absorbed with ~40% reaching systemic circulation unchanged following first-pass metabolism

Route of elimination: Sildenafil is cleared predominantly by the CYP3A (major route) and cytochrome P450 2C9 (CYP2C9, minor route) hepatic microsomal isoenzymes. After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of the administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose).

Half life: 4 hours

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Sildenafil.

Tell your doctor or pharmacist if you have any medical conditions.

Common sildenafil side effects may include: flushing (warmth, redness, or tingly feeling), headache, dizziness, abnormal vision (blurred vision, changes in color vision), runny or stuffy nose, nosebleeds, sleep problems (insomnia), muscle pain, back pain or upset stomach.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Damien
21/Aug/2024

I'm 45 and it makes me feel 20 again "down there". I take 50mg on an empty stomach with water and it works in 10 minutes. Side effects have been very mild... stuffy nose and an occasional light headache. Allows me to be very effective for about 3 to 5 hours with a quick recovery time. This is a great medicine, but don't overuse. Taking it every day is not as sweet as once or twice a week.

Jack
22/Jul/2024

Great time. I was so pleased to give my lover a good time. I am 60 but I managed to stay hard for 30 minutes before climaxing... amazing!!!

Teddy
10/Jan/2024

50 yrs. old. ED started mid 40's. Tried Cialis - sometimes worked. Got this Sildigra Softgel and WHAM! Took a test dose of 50 mg and did not tell my wife because that night I wanted to make sure it worked. 1 hours later BAM! I stopped her from making dinner and led her in the bedroom. Haven't had that stamina since I was in my 20's! Needless to say we are both smiling and glad a generic form of Viagra that works is available. YAY!!!!! is all I can say. I was about to give up and live a life of no sex...which was not an option for me.

Billy
06/Nov/2023

Was skeptical, but it sure does work, 45 minutes after a 50 mg dose had the best erection in years, was able to get a good one even the next morning. Am extremely satisfied, going to try a smaller dose, think it will be fine for me.

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